Isothermal titration calorimetry software

The software is really easy to use, it has many features that allow the user to get the maximum amount of information from a single experiment. It has plenty of information about the theory behind the technique and also allows the users to create their own model fitting. The support team is extremely helpful.

We are really happy with this new tool. The use of the software and the help of its support staff were crucial for modelling and extracting important insights into the interaction. Isothermal Titration Calorimetry ITC is a standard technique designed to characterize intermolecular interactions. AFFINImeter has been designed to really squeeze the information that can be obtained from ITC experiments, ranging from kinetic interaction constants to reaction mechanisms and thermodynamic parameters of relatively complex reactions.

Tailored Binding models Tailored Binding models Design your own binding models using an easy-to-use interface to describe processes like dimerization induced by binding, conformational changes, multisite binding and cooperativity or binding heterogeneity, to name few.

Perform a global analysis of multiple data generated from different frequencies of the spectra in a titration experiment or from different techniques. Use advanced binding models for the analysis of complex interactions. Learn more. Get a free trial. Perform automated peak tracking and binding curve generation. Carry out global analysis of binding curves obtained from different NMR signals Use advanced binding models for the analysis of complex interactions.

If the same model applies to all the measurements, the parameters of the different curves should be identical to each other. There are also situations where a different model applies to each experimental curve but one or more parameters are shared. This happens, for instance, when combining an experiment involving two competing ligands and a host with another experiment where one of the ligands is absent.

Additionally, mainly when applying complex models, you may want to correlate parameters by means of analytical or logical equations. The MicroCal VP-ITC is a powerful and sensitive, easy-to-use isothermal titration calorimeter that offers the ability to investigate any biomolecular interaction. Its fast, convenient label-free in solution analysis delivers the information needed to characterize the molecular interactions of proteins, antibodies, nucleic acids and other biomolecules.

The system is widely used in research environments for lead optimization, hit validation, assessing the driving mechanisms of binding and studying enzyme kinetics and inhibitor design. Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.

When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.